Lyon, France

Hospices Civils de Lyon

Participant 18: Hospices Civils de Lyon
Centre de Pathologie et Neuropathologie Est
Hospices Civils de Lyon
Groupement Hospitalier Est
57 Bd Pinel
69677 Bron Cedex
FRANCE

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Project Leader


Dr. David Meyronet
Phone: +33 (4) 7235 7630 
Fax: +33 (4) 7235 7067  
 
Dr. David Meyronet


Project Staff


Dr. Nathalie Streichenberger
Neuropathology
Assistant Professor Neuropathologist  

Rachel Plantier
Histology technician, Immunohistochemistry 

Patrick Hildt
Histology technician, Quality control 

Prof. Dr. Bernard Renaud
Neurochemistry
Head  Dept of Biochemistry, Director INSERM Unit 512  

Dr. Armand Perret-Liaudet
Clinical biochemist/neurochemist, Expertise in CJD and neurodegenerative diseases 

Prof. Dr. Alain Vighetto
Neurology
Head of the "Service of Neurology D", Neurologist, (Degenerative dementia, prion diseases)  

Dr. Pierre Krolak-Salmon
Assistant Professor, Neurologist (behavioral Neurology, dementia and prion diseases)  

Bernadette Mercier
Neuropsychologist (cognitive functions testing)  


Institute Presentation


Lyon institution's expertise

Over the last decades Lyon has been internationaly recognized as an important research center in both fundamental and clinical neurosciences. The Neurological Hospital of Lyon is one of the greatest neurology and neurosurgery centers in Europe, with more than 12 000 patients consulting/year, 400 beds for hospitalisation, more than 1000 cases of surgery for brain tumours. The Neurological Hospital includes or is surrounded by 18 research laboratories constituting the Lyon Federative Institut for Neurosciences (IFNL) and belonging to the Claude Bernard University (4 medical schools), the INSERM, the CNRS, and the Lyon Hospitals.

The Laboratory of Neuropathology has a long history since it was among the first created in France (1967) and possesses a large collection of cases. Its activity can be summarized as follows :

  • neuropathological activity with autopsy : about 30/years, in most cases for differential diagnosis  between CJD and atypical dementias. 
  • brain tumours diagnosis (1000/year)
  • epilepsy neurosurgery (40/year)
  • muscular pathology diagnosis (270/year)

There is a close relationship between neuropathology and biochemistry (neurochemistry unit)

  • for CJD diagnosis, both in immunohistochemistry (IHC) and Western Blot (WB)
  • for muscular pathology (IHC and WB)

There is also a close relationship between neuropathologists and neurologists, the later being highly involved, together with the neurochemists, in the development of tissue preservation within the Neurobiotec Bank. With the support of patients associations, the number of autopsies is increasing.

The Neurological Hospital has a large experience in banking: Neurobiotec, created in 1997, is one of the first biological resource centers in France. The bank collects brain tumours, muscle biopsy samples, blood, urine and CSF. Patient consents are required. Samples are frozen, cultured, and/or fixed according to validated protocols. Clinical summaries and pictures are associated with samples. High security system and recording informations have been established.

The connection of the Neuropathology and Biochemistry laboratories with fundamental research is tight:

  • with INSERM, especially for brain tumours and in vivo  and ex vivo neurochemistry 
  • for CJD diagnosis and research since one of the first L3 labs was established in the Neurological Hospital (1999) with specific equipments for histology, biochemistry and diagnosis, including a laser microdissector.

In the future:

  • modernisation of the Neurological Hospital with a new autopsy centre, new (and geographically closed) laboratories (neuropathology, biochemistry and molecular biology ). 
  • development of post banking treatments of samples (Neurobiotec service) using the most recent research technologies.



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Consortium Participants

 

Workpackage Structure