London (Imperial College), UK

Imperial College of Science, Technology and Medicine

Participant 17: Imperial College of Science, Technology and Medicine
Exhibition Road
London SW7 2AZ
United Kingdom

 homepage 

Website of University Department of Neuropathology, Imperial College London and Hammersmith Hospitals Trust (co-applicant and equal partner, reponsible for all diagnostic work): Gentleman, Roncaroli



Project Leader


Prof. Dr. Richard Reynolds
Joint principal applicant and Director of UK PD Tissue Bank 
Phone: +44 (20) 8846 7022 
Fax: +44 (20) 8846 7500 
 
Prof. Dr. Richard Reynolds


Project Staff


Dr. David Dexter

Dr. Shama Fernando
Responsible for RNA isolation and characterisation methods and gene expression profiling  

Dr. Owain Howell
Responsible for characterisation of human tissues for gene expression profiling and immunohistochemical analysis 

Dr. Vora Abhi
UK MS Tissue Bank manager. Role in managing bank, organising donor scheme, all aspects of quality control  

Dr. Kirstin Goldring
UK PD Tissue Bank manager. Role in managing bank, organising donor scheme, all aspects of quality control   

Dr. Roberta Magliozzi
PhD student studying the role of inflammation in neurodegeneration using human tissues  


Institute Presentation


THE UK MULTIPLE SCLEROSIS AND PARKINSON'S DISEASE TISSUE BANKS
IMPERIAL COLLEGE LONDON

Imperial College London is one of the major colleges of the University of London. Imperial College embodies and delivers world-class scholarship, education and research in science, engineering and medicine, with particular regard to their application in industry, commerce and healthcare. The Faculty of Medicine is one of the largest in the UK with significant research and teaching activities. It maintains close links with a number of National Health Service (NHS) Trusts who collaborate in teaching and research activities. Although on several sites, its academic divisions function as one Faculty, fully integrated within the College.

The Division of Neuroscience & Mental Health at Imperial College covers a wide range of expertise in both basic and clinical neuroscience, from the molecule through to systems approaches and on to the diagnosis and management of patients with neurological and psychiatric diseases. In other words, our research at all levels is very disease orientated. We are based on the Charing Cross, Hammersmith and St. Mary's Campuses, and our interests are particularly focused on glial biology and neuroinflammation, neurodegeneration, neurogenetics, neuroendocrinology, neuromuscular diseases, sensorimotor systems and brain and spinal cord recovery from injury.

Resource for Research   a vital gift


The UK Multiple Sclerosis (MS) and UK Parkinson's Disease (PD) Tissue Banks were established on the Charing Cross Hospital Campus of Imperial College in 1998 and 2002 respectively and are housed in the Department of Cellular and Molecular Neuroscience, funded by 5-year grants from the UK MS and PD Societies. The Tissue Banks were set up to co-ordinate the UK wide collection of brain, spinal cord and cerebral spinal fluid (CSF) at post-mortem from people who had MS or PD and to provide a reliable source of this material for researchers worldwide. All tissues are procured via a prospective donor scheme with full consent of the next-of-kin. Both tissue banks are governed by independent management boards. We have developed extensive protocols for collection, dissection and storage of brain, spinal cord and CSF, to ensure that the tissue is of maximum use for a wide variety of experimental techniques. The Banks are directed and run by two teams of research scientists in the department, headed by Professor Richard Reynolds (MS) and Dr David Dexter (PD) respectively. Neuropathological diagnostic support is provided by the Department of Neuropathology at Imperial College, headed by Professor Manuel Graeber. Neuropathological diagnosis is based on the examination of 23 selected histological blocks after traditional and immunocytochemical staining procedures. Clinical Neurology support is provided by Consultant Neurologists of the Hammersmith Hospitals Trust. Neuropathological and clinical reports are available to the next-of-kin and detailed reports are available to researchers.

The work of the Tissue Banks is complemented by extensive research programmes in both MS and PD. Experimental approaches range from gene expression profiling of damaged tissues through to preclinical trials of potential pharmacological treatments for MS and PD.

Tissue Bank websites

http://www.ukmstissuebank.org.uk/

http://www.parkinsonstissuebank.org.uk/




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Workpackage Structure