Edinburgh, UK
Participant 03: The University of Edinburgh
Neuropathology Unit
Department of Pathology
Western General Hospital
Crewe Road
Edinburgh EH4 2XU
United Kingdom

Project Leader


Prof. Dr. James W. Ironside
Phone: +44 (131) 537 3109 
Fax: +44 (131) 343 1404 
 


Project Staff


Mrs. Frances Carnie
Brain Bank Manager, (Quality Control for BNE, WP3 & WP16)  

Ms. Angela Penman
Office Manager (Communications with BNE, WP5 & 16)  

Dr. Iain Anthony
Post Doctoral Scientist (Methodological Approaches in Training & Research, WP 14)  

Dr. Jodie Morris
Technical Officer 


Institute Presentation


Summary of experience relevant to brain banking

Summary of experience relevant to brain banking
The purpose of this brain and tissue bank is to retrieve, store and make available for research use, post mortem tissue samples from individuals who have died of HIV/AIDS. This bank was set up in 1990 with the support of the UK Medical Research Council and since that date has banked many fixed and frozen tissue samples from drug users and homosexual men with AIDS, from presymptomatic HIV positive drug users and from controls, including HIV negative drug users. These samples have been made available on request to research workers in UK, mainland Europe and US, and further afield. Users are asked to provide evidence of their research intent and of ethical approval for the use of human tissue for research. This brain bank has local ethical approval for the collection and use for research of human post mortem tissue.  

As well as supporting research elsewhere the samples have been used for Edinburgh-based research in collaboration with a multidisclipinary network of colleagues. This programme of research integrates clinicopathological correlation with neuropsychological assessments, automated quantitation of pathology images, host genotyping and viral characterisation. Research has focussed mainly on the central nervous system in order to address questions about the damage inflicted on the brain by HIV infection and drug abuse.  


References


Anthony IA, Crawford DH, Bell JE. B lymphocytes in the normal brain: constrasts with HIV-associated lymphoid infiltrates and lymphomas. Brain (in press).

Anthony IC, Ramage SN, Carnie FW, Simmonds P, Bell JE. Influence of HAART on HIV related CNS disease and neuroinflammation. J Neuropath Exp Neurol (in press).

Anthony IC, Ramage SN, Carnie FW, Simmonds P, Bell JE. Does drug abuse alter microglial phenotype and cell turnover in the context of advancing HIV infection? Neuropathol Appl Neurobiol 2005; 31: 325-338.

Anthony IC, Craford DH, Bell JE. Effects of human immunodeficiency virus encephalitis and drug abuse on the B lymphocyte population of the brain. JNeurovirol 2004; 10(3): 181-188.

Anthony IC, Crawford DH, Bell JE. B lymphocytes in the normal brain: constrasts with HIV-associated lymphoid infiltrates and lymphomas. Brain 2003; 126(Pt 5): 1058-1067.

Bell JE, Arango J-C, Brettle RP, Simmonds P. HIV & drugs of abuse - double jeopardy for the CNS? AIDS (in press).

Bell JE, Brettle RP, Chiswick A, Simmonds P. HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS: effect of neocortical involvement. Brain 1998; 121: 2043-2052.

Bell, JE, Donaldson, YK, Lowrie, S, McKenzie, C, Elton, RA, Chiswick, A, Brettle, R, Ironside, JW, and Simmonds, P. Influence of risk group and zidovudine therapy on the development of HIV encephalitis and cognitive impairment in AIDS patients. AIDS 1996; 10: 493-499.

Bell JE, Brettle RP, Chiswick A, Simmonds P. HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS: effect of neocortical involvement. Brain 1998; 121: 2043-2052.

Bell, JE, Donaldson, YK, Lowrie, S, McKenzie, C, Elton, RA, Chiswick, A, Brettle, R, Ironside, JW, and Simmonds, P. Influence of risk group and zidovudine therapy on the development of HIV encephalitis and cognitive impairment in AIDS patients. AIDS 1996; 10: 493-499
Bell JE. An update on the neuropathology of HIV in the HAART era. Histopath 2004; 45: 549-559.
Bell JE, Arango J-C, Robertson R, Brettle RP, Leen CLS, Simmonds P. HIV & drug misuse in the Edinburgh cohort? AIDS 2002; 31: S35-S42.

Imlach S, McBreen S, Shirafuji T, Leen CLS, Bell JE, Simmonds P. Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by HIV-1. JVirol 2001; 75: 11555 - 11564.

Imlach S, McBreen S, Shirafuji T, Leen CLS, Bell JE, Simmonds P. Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by HIV-1. JVirol 2001; 75: 11555 ? 11564.

Ramage SN, Anthony IC, Carnie FW, Busuttil A, Robertson R, Bell JE. Hyperphosphorylated Tau deposition is increased in the brains of young drug abusers. Neuropathol Appl Neurobiol (in press).
Wang T-H, Donaldson YK, Brettle RP, Bell JE, Simmonds P. Identification of shared populations of HIV-1 infecting microglia and tissue macrophages outside the central nervous system. JVirol 2001; 75: 11686 - 11699.
Wang T-H, Donaldson YK, Brettle RP, Bell JE, Simmonds P. Identification of shared populations of HIV-1 infecting microglia and tissue macrophages outside the central nervous system. JVirol 2001; 75: 11686 - 11699.



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