WP18 - Protein Preservation

Protein degradation is a progressive and consistent phenomenon following death; abnormal protein folding, and protein degradation may occur in the agonal period as well. Yet protein integrity is crucial in the study of physiological and pathological cellular events. Therefore, information regarding the influence of agonal state, post-mortem delay, and storage of the nervous tissue is a preliminary requirement for a serious approach to the study of molecular mechanisms involved in the normal and abnormal function of the nervous system.

Among other objectives, this work package aims at:

  • identifying and characterizing proteolytic processes that occur in the brain as a result of the agonal state, after death and during post-mortem delay and storage,
  • comparing and optimising the technologies of proteome analysis to study the changes that occur in the protein profile during the post-mortem interval,
  • introducing, in the Brain Bank current practice, procedures aimed to preserve protein integrity during the post-mortem period and to introduce rapid procedures aimed to define the degree of protein preservation in the tissues stored in the Banks.

Workpackage Leader


Prof. Dr. Isidro Ferrer

Phone: +34 (93) 403 5808 
Fax: +34 (93) 260 7503 
Prof. Dr. Isidro Ferrer


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Consortium Participants

 

Workpackage Structure