Stockholm, Sweden

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Participant 04: The Brain Bank at Karolinska Institutet
Department of Neurobiology, Care Sciences and Society (NVS)
Karolinska Institutet
141 86 Stockholm, Sweden

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Manager of the Brain Bank at Karolinska Institutet

 

Professor Caroline Graff, MD PhD
Head of The Brain Bank at KI
Phone: +46 8 585 836 19
Fax: +46 8 585 83880



Project Staff

 

Bengt Winblad, Prof. MD PhD
Senior consultant and director of Alzheimer Center  

 

Anna Karin-Lindström
Biomedical Scientist and Lab Manager

 

Marie Fallström
Coordinator

 

Pär Lundkvist
Lab technician



Institute Presentation

The activities of The Brain Bank at Karolinska Institutet (The BB at KI) are closely parallel to the intensive scientific and clinical research and diagnostic procedures on neurodegenerative disorders. In particular, Alzheimer´s disease, fronto-temporal lobe dementias, vascular dementia, and age-matched control cases are being collected and studied. Thanks to the traditionally well-known Swedish demographic registration system, the pioneering work of brain collecting was facilitated. In 1972, Professor Bengt Winblad established the first national brain bank with a focus on dementia conditions in Umeå. In 1988 the brain bank was moved to Karolinska Institutet /Karolinska University Hospital in Huddinge (Stockholm), at that time coordinated by Dr. Irina Alafuzoff. 1992-2008, Dr. Nenad Bogdanovic coordinated the Huddinge Brain Bank with specific emphasis on the correlation of pathological and clinical diagnoses.

In 2010, the Huddinge Brain Bank became The Brain Bank at Karolinska Institutet and enjoys widespread collaboration activities with diverse scientific groups to employ the diagnostic procedure with biochemical, morphometrical, proteomic, and genomic data. The main principle for obtaining the tissue is the consent of patients or their families. The BB at KI is run with approval of the Ministry of Health and the Ethical Committee at the Karolinska University Hospital in Huddinge. The brain tissue is stored deep-frozen or fixed in formalin according to specific protocols for solicitation and preparation. Besides the tissue material, cerebrospinal fluid samples, and blood samples and in some cases skin fibroblast samples are collected. To date, The BB at KI has tissue samples from 753 formalin fixed and 229 frozen brains. All data is doubly encoded, saved on separate computer systems and is only accessible for the brain bank coordinator and the principal technician, in order to maintain the highest standards of data protection.


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Consortium Participants

 

Workpackage Structure