© BrainNet Europe II
BrainNet Europe is a "Network of Excellence" funded by the European Commission in the 6th Framework Program "Life Science" (LSHM-CT-2004-503039). It consists of 19 established brain banks across Europe and is coordinated by the Centre for Neuropathology and Prion Research Ludwig-Maximilians-University Munich, Germany.
Participant 04: The Brain Bank at Karolinska Institutet
Manager of the Brain Bank at Karolinska Institutet
The activities of The Brain Bank at Karolinska Institutet (The BB at KI) are closely parallel to the intensive scientific and clinical research and diagnostic procedures on neurodegenerative disorders. In particular, Alzheimer´s disease, fronto-temporal lobe dementias, vascular dementia, and age-matched control cases are being collected and studied. Thanks to the traditionally well-known Swedish demographic registration system, the pioneering work of brain collecting was facilitated. In 1972, Professor Bengt Winblad established the first national brain bank with a focus on dementia conditions in Umeå. In 1988 the brain bank was moved to Karolinska Institutet /Karolinska University Hospital in Huddinge (Stockholm), at that time coordinated by Dr. Irina Alafuzoff. 1992-2008, Dr. Nenad Bogdanovic coordinated the Huddinge Brain Bank with specific emphasis on the correlation of pathological and clinical diagnoses.
In 2010, the Huddinge Brain Bank became The Brain Bank at Karolinska Institutet and enjoys widespread collaboration activities with diverse scientific groups to employ the diagnostic procedure with biochemical, morphometrical, proteomic, and genomic data. The main principle for obtaining the tissue is the consent of patients or their families. The BB at KI is run with approval of the Ministry of Health and the Ethical Committee at the Karolinska University Hospital in Huddinge. The brain tissue is stored deep-frozen or fixed in formalin according to specific protocols for solicitation and preparation. Besides the tissue material, cerebrospinal fluid samples, and blood samples and in some cases skin fibroblast samples are collected. To date, The BB at KI has tissue samples from 753 formalin fixed and 229 frozen brains. All data is doubly encoded, saved on separate computer systems and is only accessible for the brain bank coordinator and the principal technician, in order to maintain the highest standards of data protection.
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