London (UCL), UK

Queen Square Brain Bank
Department of Molecular Neuroscience
Institute of Neurology - University College London,
Queen Square,
London WC1N 3BG
United Kingdom


Project Leader

Prof. Tamas Revesz
Phone: +44 (20) 837 8370 
Fax: +44 (20) 278 4993 
Professor Tamas Revesz

Prof. Andrew Lees
Prof. Andrew Lees

Project Staff

Dr. Janice Holton
Senior Lecturer/Consultant Neuropathologist 

Linda Parsons
Laboratory Manager 

Susan Stoneham

Dr. Ann Kingsbury
Senior Research Fellow 

Institute Presentation

Queen Square Brain Bank for Neurological disorders

Directors: Professor A. J. Lees and Professor T. Revesz

The Queen Square Brain Bank for Neurological Disorders (QSBB), at the UCL Institute of Neurology, holds a unique archive of brains donated by individuals with neurodegenerative disease and neurologically normal controls. It specialises in parkinsonian movement disorders, including Parkinson's disease and multiple system atrophy, and holds the national collection of brains donated by individuals with progressive supranuclear palsy (PSP). Recently the collection has been developed to include donated brains from prospectively studied people with dementias, in collaboration with the Dementia Research Centre at the National Hospital for Neurology and Neurosurgery, Queen Square. The QSBB also banks brains donated by people with rare disorders such as dystonia or Gilles de la Tourette syndrome.

Queen Square Brain Bank for Neurological disorders

The QSBB aims to provide the highest-possible quality of brain tissue for neuropathological studies and for scientific research both in the UK and worldwide. The large collection of tissue is backed up by good clinical documentation and all material is fully evaluated by the QSBB's neuropathologists. Its procedures have ethics committee approval and tissue comes from registered prospective donors with the informed consent of next-of-kin. The QSBB's record of prospective donors complies with the Data Protection Act. 

The QSBB holds a large archive of brains, sufficient to support statistically valid case-control studies. Brain tissue is stored as formalin-fixed, wax embedded blocks and is frozen and stored at -80 °C (flash-frozen whenever possible). Tissue can be provided as slide-mounted sections, or as small blocks for neurochemistry, proteomics and DNA and RNA analysis. Flash-frozen material has excellent histological preservation and is suitable for in situ hybridization and immunohistochemistry. Case-control studies are matched for post-mortem delay and agonal status and are supplied blind. Clinical data related to the tissue supplied are made available on an anonymised basis. The QSBB is supported by the Institute of Neurology, the Reta Lila Weston Institute of Neurological Studies and the PSP (Europe) Association.

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Consortium Participants


Workpackage Structure