WP15 - Standardisation of Neuropathological Criteria and Diagnostics

The ultimate goal is to facilitate the use of human brain tissue in research and to supply the researchers in various fields of neuroscience with brain tissue of optimal quality (see also WP01, WP03). This requires both clinical and neuropathological diagnostic security. One requirement is that both the clinical and especially the neuropathological diagnostic criteria used within the consortium are harmonised. A disease (e.g. Alzheimer's Disease) is defined as a clinical condition whereas tissue specific lesions with specific distribution are to be found. Additional to this for the diagnosis of AD, specific clinical symptoms with special progression are required. Based on the above diagnostic consensus criteria have been produced and published previously fore a selection of neurological diseases.

The objectives of this work package are:

  • To evaluate the consensus criteria already available and modify them when needed.
  • To produce novel neuropathological consensus criteria. 
  • To harmonize the diagnostic practice within the BrainNet Europe.

It should be emphasised that the BrainNet Europe consortium is dealing with neuropathological entities and if and when needed clinicians (neurologists, psychiatrists, gerontologists) are to be consulted in order to facilitate the production of clinico-pathological consensus criteria.

Workpackage Leader

Prof. Dr. Irina Alafuzoff MD PhD

Phone: +358 (17) 162877 
Fax: +358 (17) 162048 
Prof. Dr. Irina Alafuzoff MD PhD

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Workpackage Structure